A Roadmap for the Twilight Zone
نویسندگان
چکیده
منابع مشابه
A roadmap for the twilight zone: navigating United States cardiovascular career development for international trainees.
Predictions of the demise of US preeminence in the sciences appear to have been exaggerated1; at least for now, objective measurements of the investment in and the impact of biomedical research in the United States suggest that it continues to dominate Europe, Japan, and China.2 The particular inequities of access to healthcare delivery in the United States are well documented,3,4 and objective...
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To students of causality, the writings of William Cochran provide an excellent and intriguing vantage point for studying how statistics, lacking the necessary mathematical tools, managed nevertheless to cope with increasing demands for policy evaluation from observational studies. Cochran met this challenge in the years 1955-1980, when statistics was preparing for a profound, albeit tortuous tr...
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Sequence alignment of proteins and nucleic acids is a routine task in bioinformatics. Although the comparison of complete peptides, genes or genomes can be undertaken with a great variety of tools, the alignment of short DNA sequences and motifs entails pitfalls that have not been fully addressed yet. Here we confront the structural superposition of transcription factors with the sequence align...
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Assessments of the acceptability of new transplantation practices require a pinpointing of not only the meaning of death, but also the timing of death. They typically perceive elective ventilation as occurring just prior to death and non-heart-beating donor protocols as operative just after death. However, such practices in fact highlight the general vagueness and ambiguity surrounding these is...
متن کاملImproving the quality of twilight-zone alignments.
Several recent publications illustrated advantages of using sequence profiles in recognizing distant homologies between proteins. At the same time, the practical usefulness of distant homology recognition depends not only on the sensitivity of the algorithm, but also on the quality of the alignment between a prediction target and the template from the database of known proteins. Here, we study ...
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ژورنال
عنوان ژورنال: Circulation
سال: 2009
ISSN: 0009-7322,1524-4539
DOI: 10.1161/circulationaha.108.811646